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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: SemiPro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis. | Ong et al. Radiation Oncology 2010 5 22 http www.ro-journal.eom content 5 1 22 RADIATION ONCOLOGY RESEARCH Open Access Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis Zhi Yi Ong1 Rachel J Gibson2 Joanne M Bowen1 Andrea M Stringer1 Jocelyn M Darby1 Richard M Logan3 Ann SJ Yeoh1 Dorothy M Keefe4 Abstract Background Mucositis is a toxic side effect of anti-cancer treatments and is a major focus in cancer research. Pro-inflammatory cytokines have previously been implicated in the pathophysiology of chemotherapy-induced gastrointestinal mucositis. However whether they play a key role in the development of radiotherapy-induced gastrointestinal mucositis is still unknown. Therefore the aim of the present study was to characterise the expression of pro-inflammatory cytokines in the gastrointestinal tract using a rat model of fractionated radiotherapy-induced toxicity. Methods Thirty six female Dark Agouti rats were randomly assigned into groups and received 2.5 Gys abdominal radiotherapy three times a week over six weeks. Real time PCR was conducted to determine the relative change in mRNA expression of pro-inflammatory cytokines IL-1P IL-6 and TNF in the jejunum and colon. Protein expression of IL-1P IL-6 and TNF in the intestinal epithelium was investigated using qualitative immunohistochemistry. Results Radiotherapy-induced sub-acute damage was associated with significantly upregulated IL-1P IL-6 and TNF mRNA levels in the jejunum and colon. The majority of pro-inflammatory cytokine protein expression in the jejunum and colon exhibited minimal change following fractionated radiotherapy. Conclusions Pro-inflammatory cytokines play a key role in radiotherapy-induced gastrointestinal mucositis in the sub-acute onset setting. Introduction Mucositis is a debilitating side effect of cytotoxic chemotherapy CT and radiotherapy RT . It involves inflammation and mucosal ulceration of the alimentary tract resulting .
