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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: SemiCytokines levels, Severity of acute mucositis and the need of PEG tube installation during chemo-radiation for head and neck cancer a prospective pilot study. | Meirovitz et al. Radiation Oncology 2010 5 16 http www.ro-journal.eom content 5 1 16 RADIATION ONCOLOGY RESEARCH Open Access Cytokines levels Severity of acute mucositis and the need of PEG tube installation during chemo-radiation for head and neck cancer -a prospective pilot study Amichay Meirovitz13 Michal Kuten 2 3 Salem Billan3 Roxolyana Abdah-Bortnyak3 Anat Sharon4 Tamar Peretz1 Mordechai Sela4 Moshe Schaffer3 Vivian Barak1 Abstract Background The purpose of this pilot study was to detect a correlation between serum cytokine levels and severity of mucositis necessitating installation of a percutaneous endoscopic gastrostomy tube PEG in head and neck H N cancer patients receiving combined chemo-radiation therapy. Patients and Methods Fifteen patients with H N epithelial cancer were recruited to this study. All patients received radiotherapy to the H N region with doses ranging from 50-70 Gy. Chemotherapy with cisplatin carboplatin 5-fluorouracil and taxanes was given to high-risk patients using standard chemotherapy protocols. Patients were evaluated for mucositis according to WHO common toxicity criteria and blood samples were drawn for inflammatory IL-1 IL-6 IL-8 TNF-a and anti-inflammatory IL-10 cytokine levels before and during treatment. Results A positive correlation was found between IL-6 serum levels and severity of mucositis and dysphagia specifically high IL-6 levels at week 2 were correlated with a need for PEG tube installation. A seemingly contradictory correlation was found between low IL-8 serum levels and a need for a PEG tube. Conclusion These preliminary results indicating a correlation between IL-6 and IL-8 serum levels and severity of mucositis and a need for a PEG tube installation justify a large scale study. Introduction More than 60 of all squamous cell tumors of the head and neck are treated by ionizing irradiation or radiochemotherapy and more recently by radiation combined with biological treatment targeted therapy such as Erbitux 1 .
