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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: CD97 neutralisation increases resistance to collagen-induced arthritis in mice. | Available online http arthritis-research.eom content 8 5 R155 Research article CD97 neutralisation increases resistance to collagen-induced arthritis in mice Else N Kop1 Janik Adriaansen1 Tom JM Smeets1 Margriet J Vervoordeldonk1 René AW van Lier2 Jorg Hamann2 and Paul P Tak1 Division of Clinical Immunology and Rheumatology Academic Medical Center University of Amsterdam Amsterdam P.O. Box 22700 1100 DE Amsterdam The Netherlands 2Department of Experimental Immunology Academic Medical Center University of Amsterdam P.O. Box 22700 1100 DE Amsterdam The Netherlands Corresponding author Jorg Hamann J.Hamann@amc.uva.nl Received 8 Apr 2006 Revisions requested 14 Jun 2006 Revisions received 13 Sep 2006 Accepted 28 Sep 2006 Published 28 Sep 2006 Arthritis Research Therapy 2006 8 R155 doi 10.1186 ar2049 This article is online at http arthritis-research.com content 8 5 R155 2006 Kop et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Synovial tissue of rheumatoid arthritis RA patients is characterised by an influx and retention of CD97-positive inflammatory cells. The ligands of CD97 CD55 chondroitin sulfate B and a5p1 very late antigen VLA -5 are expressed abundantly in the synovial tissue predominantly on fibroblast-like synoviocytes endothelium and extracellular matrix. Based upon this expression pattern we hypothesise CD97 expression to result in accumulation of inflammatory cells in the synovial tissue of RA patients. To determine the therapeutic effect of blocking CD97 in an animal model of RA collagen-induced arthritis was induced in a total of 124 DBA J1 mice. Treatment was started on day 21 early disease or on day 35 longstanding disease with the blocking hamster anti-mouse CD97 monoclonal antibody .
