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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages. | Available online http arthritis-research.eom content 8 2 R39 Research article Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages Karin Romisch1 Frederick W Miller2 Bernhard Dobberstein3 and Stephen High4 University of Cambridge Cambridge Institute for Medical Research and Department of Clinical Biochemistry Cambridge UK Environmental Autoimmunity Group National Institute of Environmental Health Sciences National Institutes of Health HHS Bethesda Maryland USA 3Zentrum fur Molekulare Biologie der Universitat Heidelberg ZMBH Heidelberg Germany 4Faculty of Life Sciences University of Manchester UK Corresponding author Stephen High stephen.high@manchester.ac.uk Received 19 Oct 2005 Revisions requested 7 Dec 2005 Revisions received 12 Dec 2005 Accepted 3 Jan 2006 Published 26 Jan 2006 Arthritis Research Therapy 2006 8 R39 doi 10.1186 ar1 895 This article is online at http arthritis-research.com content 8 2 R39 2006 Romisch et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The 54 kDa subunit of the signal recognition particle SRP54 binds to the signal sequences of nascent secretory and membrane proteins and it contributes to the targeting of these precursors to the membrane of the endoplasmic reticulum ER . At the ER membrane the binding of the signal recognition particle SRP to its receptor triggers the release of SRP54 from its bound signal sequence and the nascent polypeptide is transferred to the Sec61 translocon for insertion into or translocation across the ER membrane. In the current article we have characterized the specificity of anti-SRP54 autoantibodies which are highly characteristic of polymyositis patients and investigated the
