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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody. | Available online http arthritis-research.eom content 7 4 R714 Research article Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody Anne-Sophie Rouziere1 Christian Kneitz1 Arumugam Palanichamy1 Thomas Dorner2 and Hans-Peter Tony1 Department of Medicine II Rheumatology and Clinical Immunology University of Wuerzburg Germany 2Charité University Hospital Berlin Germany Corresponding author Hans-Peter Tony Tony_H@medizin.uni-wuerzburg.de Received 5 Aug 2004 Revisions requested 10 Sep 2004 Revisions received 1 Mar 2005 Accepted 7 Mar 2005 Published 1 Apr 2005 Arthritis Research Therapy 2005 7 R714-R724 DOI 10.11 86 ar1 731 This article is online at http arthritis-research.com content 7 4 R714 2005 Rouziere et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract B-cell depletive therapies have beneficial effects in patients suffering from rheumatoid arthritis. Nevertheless the role of B cells in the pathogenesis of the disease is not clear. In particular it is not known how the regeneration of the B-cell repertoire takes place. Two patients with active rheumatoid arthritis were treated with rituximab and the rearranged immunoglobulin heavy-chain genes Ig-VH were analysed to follow the B-cell regeneration. Patient A was treated with two courses of rituximab and B-cell regeneration was followed over 27 months by analysing more than 680 Ig-VH sequences. Peripheral B-cell depletion lasted 7 months and 10 months respectively and each time was accompanied by a clinical improvement. Patient B received one treatment course. B-cell depletion lasted 5 months and was accompanied by a good clinical response. B cells regenerated well in both patients and the .