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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:ANKH variants associated with ankylosing spondylitis: gender differences. | Available online http arthritis-research.eom content 7 3 R513 Research article ANKH variants associated with ankylosing spondylitis gender differences Hing Wo Tsui1 Robert D Inman1 2 Andrew D Paterson2 3 John D Reveille4 and Florence WL Tsui1 2 Open Access Toronto Western Research Institute Toronto Ontario Canada 2University of Toronto Toronto Ontario Canada 3The Hospital for Sick Children Toronto Ontario Canada 4The University of Texas-Houston Health Science Center Houston Texas USA Corresponding author Florence WL Tsui ftsui@uhnres.utoronto.ca Received 27 Oct 2004 Revisions requested 16 Dec 2004 Revisions received 21 Jan 2005 Accepted 24 Jan 2005 Published 25 Feb 2005 Arthritis Research Therapy 2005 7 R513-R525 DOI 10.1186 ar1701 This article is online at http arthritis-research.com content 7 3 R513 2005 Tsui et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The ank progressive ankylosis mutant mouse which has a nonsense mutation in exon 12 of the inorganic pyrophosphate regulator gene ank exhibits aberrant joint ankylosis similar to human ankylosing spondylitis AS . We previously performed family-based association analyses of 124 Caucasian AS families and showed that novel genetic markers in the 5 flanking region of ANKH the human homolog of the murine ank gene are modestly associated with AS. The objective of the present study was to conduct a more extensive evaluation of ANKH variants that are significantly associated with AS and to determine whether the association is gender specific. We genotyped 201 multiplex AS families with nine ANKH intragenetic and two flanking microsatellite markers and performed family-based association analyses. We showed that ANKH variants located in two different regions of .
