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Báo cáo y học: "Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritis. | Available online http arthritis-research.eom content 7 3 R592 Research article Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritis Gilles Boire1 Pierre Cossette2 Artur J de Brum-Fernandes1 Patrick Liang1 Théophile Niyonsenga3 Zhijie J Zhou4 Nathalie Carrier3 Claude Daniel5 and Henri-A Ménard4 Department of Medicine Division of Rheumatology University of Sherbrooke Sherbrooke Quebec Canada 2Department of Medicine Division of Internal Medicine University of Sherbrooke Sherbrooke Quebec Canada 3Centre de recherches cliniques Centre hospitalier universitaire de Sherbrooke CHUS Sherbrooke Québec Canada 4Division of Rheumatology Department of Medicine McGill University Health Centre Montréal Quebec Canada 5Laboratoire d histocompatibilité Université du Québec INRS-Institut Armand-Frappier Laval Québec Canada Corresponding author Gilles Boire Gilles.Boire@USherbrooke.ca Received 10 Dec 2004 Revisions requested 6 Jan 2005 Revisions received 16 Feb 2005 Accepted 18 Feb 2005 Published 17 Mar 2005 Arthritis Research Therapy 2005 7 R592-R603 DOI 10.11 86 ar1 719 This article is online at http arthritis-research.com content 7 3 R592 2005 Boire et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The prognostic value of two antibodies targeting citrullinated antigens anti-Sa and anti-cyclic citrullinated peptide CCP present at inclusion was evaluated prospectively in a cohort of 165 consecutive patients with recent-onset or early polyarthritis EPA followed for up to 30 months. Patients were treated according to current Good Clinical Practice standards. Predefined outcomes were severe arthritis and .