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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Autoantibody profiling for the study and treatment of autoimmune disease. | Arthritis Research Vol 4 No 5 Hueber et al. Review Autoantibody profiling for the study and treatment of autoimmune disease Wolfgang Hueber1 Paul J Utz1 3 Lawrence Steinman2 3 and William H Robinson1 2 3 1 Department of Medicine Division of Rheumatology and Immunology Stanford University School of Medicine Stanford California USA 2Department of Neurology and Neurological Sciences Stanford University School of Medicine Stanford California USA 3Tolerion Palo Alto California USA Corresponding author William H Robinson e-mail wrobins@stanford.edu Received 24 January 2002 Revisions received 5 March 2002 Accepted 11 March 2002 Published 7 May 2002 Arthritis Res 2002 4 290-295 2002 BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract Proteomics technologies enable profiling of autoantibody responses using biological fluids derived from patients with autoimmune disease. They provide a powerful tool to characterize autoreactive B-cell responses in diseases including rheumatoid arthritis multiple sclerosis autoimmune diabetes and systemic lupus erythematosus. Autoantibody profiling may serve purposes including classification of individual patients and subsets of patients based on their autoantibody fingerprint examination of epitope spreading and antibody isotype usage discovery and characterization of candidate autoantigens and tailoring antigen-specific therapy. In the coming decades proteomics technologies will broaden our understanding of the underlying mechanisms of and will further our ability to diagnose prognosticate and treat autoimmune disease. Keywords autoantibodies autoimmune disease proteomics protein arrays Introduction Proteomics is the large-scale study of expression function and interactions of proteins 1 . Recent advances in the field spawned miniaturized proteomics technologies capable of parallel detection of thousands of different antigens using submicroliter quantities of biological fluids. This review will focus on proteomics .
