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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A colliding maxillary sinus cancer of adenosquamous carcinoma and small cell neuroendocrine carcinoma - a case report with EGFR copy number analysis | Huang et al. World Journal of Surgical Oncology 2010 8 92 http www.wjso.eom content 8 1 92 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access A colliding maxillary sinus cancer of adenosquamous carcinoma and small cell neuroendocrine carcinoma - a case report with EGFR copy number analysis Shiang-Fu Huang1 Wen-Yu Chuang2 Sou-De Cheng3 Li-Jen Hsin1 Li-Yu Lee2 Huang-Kai Kao4 Abstract Background Small cell neuroendocrine carcinoma SNEC of maxillary sinus is a rare and aggressive malignancy. A tumor with squamous cell carcinoma adenocarcinoma and SNEC co-existence is extremely rare. Case presentation We present a colliding tumor of squamous cell adenocarcinoma and SNEC in maxillary sinus. The clinical features diagnosis and EGFR flourescence in situ hybridization FISH study are presented. A 52-year-old female had a 1-month history of progressing left cheek swelling and purulent rhinorrhea. Magnetic resonance imaging showed a tumor involving left maxilla and orbital floor. Excision of tumor was done and the defect was reconstructed with free flap. The pathology revealed a malignant tumor composed of squamous cell carcinoma adenocarcinoma and SNEC components. EGFR FISH study showed no gene amplification in 3 components of this tumor. The tumor progressed rapidly and the patient expired at 8 months after surgery. Conclusion A colliding tumor of squamous cell adenocarcinoma and neuroendocrine carcinoma in maxillary sinus was aggressive in behavior and the treatment response was poor due to the complexity of tumor. Introduction Carcinoma of the paranasal sinuses accounts for about 0.3 of all cancers 1 . Most of the malignancies in paranasal sinus is squamous cell carcinoma SCC and followed by adenocarcinoma. Small cell neuroendocrine carcinoma SNEC is a rare tumor in head and neck region and it occurs most frequently in larynx 2 . Paranasal sinuses are uncommon primary sites for the occurrence of extrapulmonary SNECs. Only small series and case reports were .
