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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Colorectal carcinoma associated with schistosomiasis: a possible causal relationship | H Salim et al. World Journal of Surgical Oncology 2010 8 68 http www.wjso.eom content 8 1 68 WORLD JOURNAL OF SURGICAL ONCOLOGY REVIEW Open Access Colorectal carcinoma associated with schistosomiasis a possible causal relationship Omer E H Salim1 2t Hytham K S Hamid 2 f Salwa O Mekki3t Suleiman H Suleiman1 2t Shakir Z Ibrahim1 2t Abstract The association between schistosomiasis and colorectal malignancy has long been suggested in the literature but it is not uniformly accepted. In the Far East considerable evidence supports an etiological link between Schistosoma japonicum and colorectal cancer. However the available data regarding the role of Schistosoma mansoni in colorectal carcinogenesis are conflicting and most often do not show causality. We report on a patient with sigmoid colonic cancer coexisting with schistosomiasis and we provide a comprehensive review of the literature regarding the epidemiology and pathobiology of this association. Background Schistosomiasis is a fairly prevalent communicable disease in tropics and subtropics caused by a trematode of the genus schistosoma. It affects more than 200 million people worldwide with over 700 million living under conditions favouring transmission 1 . Human schistosomiasis is generally caused by three major species Schistosoma mansoni S. mansoni endemic in Africa the Middle East and South America Schistosoma japonicum S. japonicum common in Southeast Asia and Schistosoma haematobium S. haematobium prevails in Africa and the Middle East 1 . In endemic areas schistosomal infestation has been implicated in the aetiology of several human malignancies including bladder liver and colorectal cancer CRC 2 . However while sufficient evidence supports a causal relationship between S. hematobium infection and bladder cancer the association between schistosomal infestation and CRC has apparently low status within the canons of medicine and reports from the publishing world 3 . Furthermore most of the published data refer
