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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Granulosa cell tumor of the ovary and antecedent of adjuvant tamoxifen use for breast cancer | Abahssain et al. World Journal of Surgical Oncology 2010 8 67 http www.wjso.eom content 8 1 67 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Granulosa cell tumor of the ovary and antecedent of adjuvant tamoxifen use for breast cancer 1 1 2 1 1 Halima Abahssain Mouna Kairouani Robert Gherman Hind MRabti Hassan Errihani Abstract Background Adult granulosa cell tumor associated with antecedent use of tamoxifen as adjuvant hormonotherapy for breast cancer is rare. The pathogenesis of this occurrence remains difficult to explain. The estrogenic effect of tamoxifen can be one such explanation. Case presentation A 47 year-old women was treated with surgery chemotherapy radiotherapy and tamoxifen for stage III estrogen receptor positive breast carcinoma. Ten months after stopping tamoxifen we diagnosed a stage Ic granulosa cell tumor of the ovary. Conclusions Use of tamoxifen has been found to be associated with gynecological tumors like endometrial carcinoma. Its association with granulosa cell tumor of the ovary is uncommon. Only two previous cases have been reported in literature. Background Granulosa cell tumor is a relatively uncommon ovarian neoplasm accounting for 1 to 2 of all ovarian tumors 1 . Tamoxifen is a non steroidal triphenylethylene that competitively antagonizes the binding of estradiol to estrogen receptor-positive breast carcinoma 2-5 . The occurrence of granulosa cell tumors in patients with antecedent tamoxifen has been previously reported in two patients 6 7 . Although tamoxifen has anti-estrogenic properties it is converted to several metabolites that can act as estrogen agonists 6 . We report the third case of granulosa cell tumor of the ovary associated with tamoxifen use for breast carcinoma. Case presentation A 47-year-old gravidia 3 para 3 women with chemotherapy induced menopause had been diagnosed with stage III T2 N2M0 infiltrating ductal carcinoma of the right breast 5 years before the development of a bilateral granulosa cell
