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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Collagen-induced arthritis is exacerbated in IL-10-deficient mice. | Arthritis Research and Therapy Vol 5 No 1 Finnegan et al. Research article Open Access Collagen-induced arthritis is exacerbated in IL-10-deficient mice Alison Finnegan1 2 Charles D Kaplan2 Yanxia Cao1 Hermann Eibel3 Tibor T Glant2 4 and Jian Zhang2 4 Department of Medicine Section of Rheumatology Rush Presbyterian-St Luke s Medical Center Chicago Illinois USA 2Department of Immunology and Microbiology Rush Presbyterian-St Luke s Medical Center Chicago Illinois USA 3Klinische Forschergruppe fur Rheumatologie Freiburg Germany 4Department of Orthopedic Surgery and Department of Biochemistry Rush Presbyterian-St Luke s Medical Center Chicago Illinois USA Corresponding author Alison Finnegan e-mail Alison_Finnegan@rush.edu Received 11 July 2002 Revisions received 13 August 2002 Accepted 11 September 2002 Published 21 October 2002 Arthritis Res Ther 2003 5 R18-R24 DOI 10.1186 ar601 2003 Finnegan et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Abstract IL-10 is a potent immunoregulatory cytokine attenuating a wide range of immune effector and inflammatory responses. In the present study we assess whether endogenous levels of IL-10 function to regulate the incidence and severity of collagen-induced arthritis. DBA 1 wildtype WT heterozygous IL-10 - and homozygous IL-10- - IL-10-deficient mice were immunized with type II collagen. Development of arthritis was monitored over time and collagen-specific cytokine production and anticollagen antibodies were assessed. Arthritis developed progressively in mice immunized with collagen and 100 of the WT IL-10 - and IL-10- - mice were arthritic at 35 days. However the severity of arthritis in the IL-10- - mice was significantly greater than that in WT or IL-1 - animals. Disease severity was .
