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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Lower paraoxonase 1 activity in Tunisian bipolar I patients. | Ezzaher et al. Annals of General Psychiatry 2010 9 36 http www.annals-general-psychiatry.eom content 9 1 36 ANNALS OF GENERAL PSYCHIATRY PRIMARY RESEARCH Open Access Lower paraoxonase 1 activity in Tunisian bipolar I patients 12 1.2 2 1 1 1.2 Asma Ezzaher Dhouha Haj Mouhamed Anwar Mechri Manel Araoud Fadoua Neffati Wahiba Douki Lotfi Gaha2 Mohamed Fadhel Najjar1 Abstract Background The purpose of this study was to investigate the variations of paraoxonase activity and lipid profile in bipolar I patients and the association of this activity with the sociodemographic clinical and therapeutic characteristics of this population. Patients and methods Our study included 66 patients with bipolar I disorder and 64 controls aged 37.9 12.6 and 36.3 18.2 years respectively. Paraoxonase activity was determined by kinetic methods high-density lipoprotein cholesterol c-HDL low-density lipoprotein cholesterol c-LDL triglycerides and total cholesterol were determined by enzymatic methods apolipoprotein Apo A1 ApoB and lipoprotein a Lp a were determined by immunoturbidimetry using Konelab 30 equipment Thermo Scientific . Results Compared with controls patients had a significantly lower paraoxonase activity and ApoA1 level and significantly higher total cholesterol c-LDL and Lp a level and ApoB ApoA1 ratio. Furthermore paraoxonase activity was significantly correlated with c-HDL values r 0.5612 P 0.001 . The lowest paraoxonase activity was noted in relation to age and body mass index BMI . Moreover it was associated with gender but not with smoking and alcohol consumption status. In patients there was no significant change in paraoxonase activity in relation to illness episodes whereas the lowest values of this activity were seen in manic patients. In contrast paraoxonase activity was significantly associated with treatment. Indeed patients taking lithium had the lowest levels. Conclusions Bipolar patients had a significant decrease in paraoxonase activity and perturbations in their