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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: 5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population. | Available online http arthritis-research.eom content 11 2 403 Letter 5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population Holger Kirsten1 2 3 Jana Burkhardt1 Helene Hantmann2 Nico Hunzelmann4 Peter Vaith5 Peter Ahnert1 6 and Inga Melchers7 11nstitute of Clinical Immunology and Transfusion Medicine Center for Biotechnology and Biomedicine BBZ University of Leipzig Johannisallee 04103 Leipzig Germany 2Fraunhofer Institute for Cell Therapy and Immunology Perlickstr. 04103 Leipzig Germany 3Translational Center for Regenerative Medicine University of Leipzig Phillip-Rosenthal-Str. 04103 Leipzig Germany 4Department of Dermatology University of Cologne Kerpener StraBe 50924 Cologne Germany 5Department of Rheumatology and Clinical Immunology University Medical Center Freiburg Hugstetter Str. 79106 Freiburg Germany institute for Medical Informatics Statistics and Epidemiology University of Leipzig Haertelstr. 16-18 04107 Leipzig Germany 7Clinical Research Unit for Rheumatology University Medical Center Breisacher Str. 79106 Freiburg Germany These authors contributed equally to this work. Corresponding author Inga Melchers inga.melchers@uniklinik-freiburg.de Published 26 March 2009 Arthritis Research Therapy 2009 11 403 doi 10.1186 ar2606 This article is online at http arthritis-research.com content 11 2 403 2009 BioMed Central Ltd See related research by Beretta et al. http arthritis-research.com content 10 5 R103 and related letter by Beretta and Scorza http arthritis-research.com content 11 2 404 Recently Beretta and colleagues 1 reported a protective association of the serotonin 5-HT2A receptor gene polymorphism His452Tyr C 1354T rs6314 with systemic sclerosis SSc in an Italian population. 5HT2A accounts for most vasoconstrictive and platelet aggregation due to serotonin activity 2 . Beretta and colleagues also demonstrated that plasma from healthy heterozygous carriers of His452Tyr showed decreased platelet aggregation after serotonin .
