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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes. | Available online http arthritis-research.eom content 11 1 R10 Research article Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes Therese Lindvall1 Jenny Karlsson1 3 Rikard Holmdahl1 and Ảsa Andersson2 Department of Experimental Medical Science Unit for Medical Inflammation Research BMC I11 Lund University S-221 84 Lund Sweden department of Pharmacology and Pharmacotherapy Faculty of Pharmaceutical Sciences Copenhagen University Universitetsparken 2 DK-2100 Copenhagen 0 Denmark 3Current address Pathology and Laboratory Medicine University of California Los Angeles 675 S. Charles E. Young Drive Los Angeles CA 90095 USA Corresponding author Therese Lindvall therese.lindvall@med.lu.se Received 18 Jul 2008 Revisions requested 9 Aug 2008 Revisions received 2 Dec 2008 Accepted 20 Jan 2009 Published 20 Jan 2009 Arthritis Research Therapy 2009 11 R10 doi 10.1186 ar2597 This article is online at http arthritis-research.com content 11 1 R10 2009 Lindvall et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction In a cross between two mouse strains the susceptible B10.RIII H-2r and resistant RIIIS J H-2r strains a locus on mouse chromosome 5 Eae39 was previously shown to control experimental autoimmune encephalomyelitis EAE . Recently quantitative trait loci QTL linked to disease in different experimental arthritis models were mapped to this region. The aim of the present study was to investigate whether genes within Eae39 in addition to EAE control development of collagen-induced arthritis CIA . Methods CIA induced by immunisation with bovine type II collagen was studied in Eae39 congenic and sub-interval congenic mice. Antibody titres were investigated with .
