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Báo cáo y học: "The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnove"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover. | Available online http arthritis-research.eom content 11 1 R9 Research article The response to oestrogen deprivation of the cartilage collagen degradation marker CTX-II is unique compared with other markers of collagen turnover Anne-Christine Bay-Jensen1 Nadine CB Tabassi2 Lene V Sondergaard3 4 Thomas L Andersen1 Frederik Dagnaes-Hansen4 Patrick Garnero2 Moustapha Kassem5 and Jean-Marie Delaissé1 Department of Clinical Cell Biology IRS CSFU University of Southern Denmark Vejle Hospital Kabbeltoft 25 7100 Vejle Denmark 2Department of Biomarkers Synarc 16 rue Montbrillant Buroparc T4 69416 LYON cedex 03 France institute of Human Genetics University of Aarhus Wilhelm Meyers Allé build. 1240 8000 Arhus C Denmark 4Department of Microbiology and immunology University of Aarhus Wilhelm Meyers Allé build. 1 240 8000 Arhus C Denmark department of Clinical Endocrinology and Molecular Biology University of Southern Winsloev Parken 25 5000 Odense C Denmark Corresponding author Jean-Marie Delaissé jean-marie.delaisse@vgs.regionsyddanmark.dk Received 24 Jun 2008 Revisions requested 8 Sep 2008 Revisions received 8 Dec 2008 Accepted 20 Jan 2009 Published 20 Jan 2009 Arthritis Research Therapy 2009 11 R9 doi 1 0.1186 ar2596 This article is online at http arthritis-research.com content 11 1 R9 2009 Bay-Jensen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The urinary level of the type II collagen degradation marker CTX-II is increased in postmenopausal women and in ovariectomised rats suggesting that oestrogen deprivation induces cartilage breakdown. Here we investigate whether this response to oestrogen is also true for other type II collagen turnover markers known to be affected in osteoarthritis .