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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF -1 in cultured rat nucleus pulposus cells. | Available online http arthritis-research.eom content 10 6 R140 Research article Synergistic role of c-Myc and ERK1 2 in the mitogenic response to TGFP-1 in cultured rat nucleus pulposus cells Tomoko Nakai1 Joji Mochida1 2 and Daisuke Sakai1 2 1 Division of Organogenesis Research Center for Regenerative Medicine Tokai University School of Medicine Shimokasuya 1 43 Isehara Kanagawa 259-1193 Japan department of Orthopaedic Surgery Surgical Science Tokai University School of Medicine Shimokasuya 1 43 Isehara Kanagawa 259-1193 Japan Corresponding author Daisuke Sakai daisakai@is.icc.u-tokai.ac.jp Received 21 May 2008 Revisions requested 1 Aug 2008 Revisions received 29 Nov 2008 Accepted 5 Dec 2008 Published 5 Dec 2008 Arthritis Research Therapy 2008 10 R140 doi 10.1186 ar2567 This article is online at http arthritis-research.com content 10 6 R140 2008 Nakai et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Although transforming growth factor P1 TGFP1 is known to be a potent inhibitor of proliferation in most cell types it accelerates proliferation in certain mesenchymal cells such as articular chondrocytes and nucleus pulposus cells. The low ability for self-renewal of nucleus pulposus cells is one obstacle in developing new therapeutic options for intervertebral disc diseases and utilizing cytokines is one of the strategies to regulate nucleus pulposus cell proliferation. However the precise cell cycle progression and molecular mechanisms by which TGFP1 stimulates cell growth remain unclear. The aim of this study was to elucidate a mechanism that enables cell proliferation with TGFP1 stimulation. Methods We tested cultured rat nucleus pulposus cells for proliferation and cell cycle .
