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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Aggrecanases and cartilage matrix degradation. | Arthritis Research Therapy Vol 5 No 2 Nagase and Kashiwagi Review Aggrecanases and cartilage matrix degradation Hideaki Nagase and Masahide Kashiwagi The Kennedy Institute of Rheumatology Division Faculty of Medicine Imperial College London London UK Corresponding author Hideaki Nagase e-mail h.nagase@imperial.ac.uk Received 9 December 2002 Revisions received 14 January 2003 Accepted 21 January 2003 Published 14 February 2003 Arthritis Res Ther 2003 5 94-103 DOI 10.1186 ar630 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract The loss of extracellular matrix macromolecules from the cartilage results in serious impairment of joint function. Metalloproteinases called aggrecanases that cleave the Glu373-Ala374 bond of the aggrecan core protein play a key role in the early stages of cartilage destruction in rheumatoid arthritis and in osteoarthritis. Three members of the ADAMTS family of proteinases ADAMTS-1 ADAMTS-4 and ADAMTS-5 have been identified as aggrecanases. Matrix metalloproteinases which are also found in arthritic joints cleave aggrecans but at a distinct site from the aggrecanases i.e. Asn341-Phe342 . The present review discuss the enzymatic properties of the three known aggrecanases the regulation of their activities and their role in cartilage matrix breakdown during the development of arthritis in relation to the action of matrix metalloproteinases. Keywords ADAMTS chondrocytes matrix metalloproteinases osteoarthritis Introduction Cartilage consists of a relatively small number of chondrocytes and abundant extracellular matrix ECM components. While numerous macromolecules have been identified in cartilage the major constituents are collagen fibrils and aggrecan a large aggregating proteoglycan 1 . Collagen fibrils consisting mainly of type II collagen and to a lesser extent of collagen type IX and type XI form an oriented meshwork that provides the cartilage with tensile strength. Aggrecans fill the interstices of the collagen .
