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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review. | Annals of General Psychiatry BioMed Central Review Open Access Efficacy and safety of aripiprazole in the treatment of bipolar disorder a systematic review Konstantinos N Fountoulakis 1 and Eduard Vieta2 Address Third Department of Psychiatry School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece and 2Bipolar Disorders Program Hospital Clinic University of Barcelona IDIBAPS CIBERSAM Barcelona Spain Email Konstantinos N Fountoulakis -kfount@med.auth.gr EduardVieta-evieta@clinic.ub.es Corresponding author Published 27 July 2009 Received 3 May 2009 Annals of General Psychiatry 2009 8 16 doi 10.1186 1744-859X-8-16 Accepted 27 July 2009 This article is available from http www.annals-general-psychiatry.com content 8 1 16 2009 Fountoulakis and Vieta licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The current article is a systematic review concerning the efficacy and safety of aripiprazole in the treatment of bipolar disorder. Methods A systematic Medline and repositories search concerning the usefulness of aripiprazole in bipolar disorder was performed with the combination of the words aripiprazole and bipolar . Results The search returned 184 articles and was last updated on 15 April 2009. An additional search included repositories of clinical trials and previous systematic reviews specifically in order to trace unpublished trials. There were seven placebo-controlled randomised controlled trials RCTs six with comparator studies and one with add-on studies. They assessed the usefulness of aripiprazole in acute mania acute bipolar depression and during the maintenance phase in comparison to placebo lithium or haloperidol. Conclusion Aripiprazole appears effective for the treatment and .
