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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Can Urine Lamivudine Be Used to Monitor Antiretroviral Treatment Adherence? | Journal of the International AIDS Society BioMed Central Research article Can Urine Lamivudine Be Used to Monitor Antiretroviral Treatment Adherence Agibothu K Hemanth Kumar1 Geetha Ramachandran2 Periyaiyah Kumar3 Vasanthapuram Kumaraswami4 and Soumya Swaminathan 4 Address Research Assistant Tuberculosis Research Centre ICMR Chetput Chennai India 2Research Officer Tuberculosis Research Centre ICMR Chetput Chennai India 3Junior Research Fellow Tuberculosis Research Centre ICMR Chetput Chennai India and 4Deputy Director Senior Grade Tuberculosis Research Centre ICMR Chetput Chennai India Email Soumya Swaminathan - doctorsoumya@yahoo.com Corresponding author Open Access Published 13 December 2006 Journal of the International AIDS Society 2006 8 53 This article is available from http www.jiasociety.Org content 8 4 53 Abstract Patient adherence to treatment is an important factor in the effectiveness of antiretroviral regimens. Adherence to treatment could be monitored by estimation of antiretroviral drugs in biological fluids. We aimed to obtain information on the quantity and duration of excretion of lamivudine in urine following oral administration of a single dose of 300 mg and to assess its suitability for adherence monitoring purposes. Spot urine samples were collected before dosing and at 4 8 12 24 28 32 48 72 and 96 hours post dosing from 10 healthy subjects and lamivudine was estimated by high-pressure liquid chromatography HPLC . Lamivudine values were expressed as a ratio of urine creatinine. About 91 of the ingested drug was excreted by 24 hours and the concentration thereafter in urine was very negligible. A lamivudine value of 0.035 mg mg creatinine or less at 48 hours is suggestive of a missed dose in the last 24 hours. The study findings showed that estimation of urine lamivudine in spot specimens could be useful in monitoring patient adherence to antiretroviral treatment. However this needs to be confirmed on a larger sample size and among patients on .
