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Modification of the surface of these vectors is a key element for their successful research and clinical use. Chapter three discusses the methods to modify surfaces of retroviral vectors, and the applications for surface modification of retroviral vectors, such as targeting and immune modulation. Chapter four reviews the role of the nuclear glucocorticoid receptor in controlling retroviral infection and function, and highlights its potential importance in retroviral-based gene therapy applications | GENE THERAPY APPLICATIONS Edited by Chunsheng Kang INTECHWEB.ORG Gene Therapy Applications Edited by Chunsheng Kang Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access articles distributed under the Creative Commons Non Commercial Share Alike Attribution 3.0 license which permits to copy distribute transmit and adapt the work in any medium so long as the original work is properly cited. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published articles. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Romina Krebel Technical Editor Teodora Smiljanic Cover Designer Jan Hyrat Image Copyright Kesu 2010. Used under license from Shutterstock.com First published July 2011 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org Gene Therapy Applications Edited by Chunsheng Kang p. cm. ISBN 978-953-307-541-9 ikrrr iJ OPEN ACCESS INI Cvn PUBLISHER INTECH open free online editions of InTech Books and Journals can be found at .
