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The role of immune complexes formed in situ has been most extensively studied in the Heymann nephritis model in the rat, a human counterpart of membranous nephropathy (MN). This is a non-proliferative form of GN in which the humoral, Th2 responses play an important role. In human idiopathic MN, an increase in the percentage of IL-4 (Masutani et al. 2004) and IL-10 (Hirayama et al. 2002) was observed in peripheral blood T cells, which correlated with the amount of proteinuria. Following induction of the disease, antibodies against gp330, megalin (Cavallo 1994; Ronco and Debiec 2005), are deposited at the subepithelial space of the glomerulus and trigger podocyte injury. | BIOMECHANICS IN APPLICATIONS Edited by Václav Klika INTECHWEB.ORG Biomechanics in Applications Edited by Václav Klika Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access articles distributed under the Creative Commons Non Commercial Share Alike Attribution 3.0 license which permits to copy distribute transmit and adapt the work in any medium so long as the original work is properly cited. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published articles. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Iva Simcic Technical Editor Teodora Smiljanic Cover Designer Jan Hyrat Image Copyright Katrina Leigh 2010. Used under license from Shutterstock.com First published August 2011 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org Biomechanics in Applications Edited by Václav Klika p. cm. 978-953-307-969-1 ikrrr iJ OPEN ACCESS INI Cvn PUBLISHER INTECH open free online editions of InTech Books and Journals can be found at .
