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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Human herpesvirus 8 – A novel human pathogen | Virology Journal BioMed Central Review Human herpesvirus 8 - A novel human pathogen Daniel C Edelman Open Access Address University of Maryland Baltimore School of Medicine Department of Pathology 725 West Lombard Street Rm. S407 Baltimore Maryland 21201 USA Email Daniel C Edelman - dedelman@umaryland.edu Corresponding author Published 02 September 2005 Received 15 July 2005 Accepted 02 September 2005 Virology Journal 2005 2 78 doi 10.1186 1743-422X-2-78 This article is available from http www.virologyj.cOm content 2 1 78 2005 Edelman licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract In 1994 Chang and Moore reported on the latest of the gammaherpesviruses to infect humans human herpesvirus 8 HHV-8 1 . This novel herpesvirus has and continues to present challenges to define its scope of involvement in human disease. In this review aspects of HHV-8 infection are discussed such as the human immune response viral pathogenesis and transmission viral disease entities and the virus s epidemiology with an emphasis on HHV-8 diagnostics. 1. The Herpesviruses I.A. Classification of herpesviruses More than 100 herpesviruses have been discovered of which all are double-stranded DNA viruses that can establish latent infections in their respective vertebrate hosts however only eight regularly infect humans. The Herpes-virinea family is subdivided into three subfamilies the Alpha- Beta- or Gammaherpesvirinea. This classification was created by the Herpesvirus Study Group of the International Committee on Taxonomy of Viruses using biological properties and it does not rely upon DNA sequence homology. However researchers have been able to identify and appropriately characterize the viral subfamilies using DNA sequence analysis of the
