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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis. | Int. J. Med. Sci. 2010 7 272 Research Paper International Journal of Medical Sciences 2010 7 5 272-277 Ivyspring International Publisher. All rights reserved Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis Rui-dan Zheng1 Cheng-run Xu1 Li Jiang1 Ai-xia Dou 2 Kun Zhou 2 Lun-gen Lu2 H 1. Research and Therapy Center for Liver Diseases Southeast Hospital Zhangzhou 363000 China 2. Department of Gastroenterology Shanghai First People s Hospital Shanghai Jiaotong University School of Medicine Shanghai 200080 China ISI Corresponding author Lun-Gen Lu M.D. Department of Gastroenterology Shanghai First People s Hospital Shanghai Jiaotong University School of Medicine Shanghai 200080 China. Tel 86-21-63240090 Fax 86-21-63241377 E-mail live.0000@live.cn Received 2010.05.05 Accepted 2010.08.08 Published 2010.08.11 Abstract Objective To investigate predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B CHB patients and their diagnostic values in hepatic inflammation and fibrosis. Methods A total of 106 HBeAg-negative CHB patients with clinically and pathologically proven steatosis and 98 patients without steatosis were recruited into this study. The levels of fasting blood glucose FBG fasting insulin FINS triglyceride TG cholesterol CHOL alanine aminotransferase ALT aspartate aminotransferase AST albumin Alb globulin Glb HBV DNA body mass index BMI homeostatic model assessment of insulin resistance HOMA-IR and pathological changes of the liver in inflammation fibrosis and fatty deposition were examined in all patients. Results The levels of BMI HOMA-IR FBG insulin TG and CHOL were significantly higher in patients with steatosis than those without steatosis all p 0.05 . But ALT AST and HBV DNA levels were significantly lower in patients with steatosis all p 0.05 . Logistic regression analysis showed that only FINS was a significant predictor for hepatic steatosis P 0.05 FINS and Glb were
