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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: A Voxel-based Morphometric Analysis of Cerebral Gray Matter in Subcortical Ischemic Vascular Dementia Patients and Normal Aged Controls. | Int. J. Med. Sci. 2011 8 482 o IVYSPRING -i fN.ii -i fl. International Journal of Medical Sciences 2011 8 6 482-486 Research Paper A Voxel-based Morphometric Analysis of Cerebral Gray Matter in Subcortical Ischemic Vascular Dementia Patients and Normal Aged Controls Chuanming Li1 Hanjian DulX Jian Zheng2 and Jian Wang1 1. Department of Radiology Southwest Hospital Third Military Medical University Chongqing China 2. Department of Neurology Xinqiao Hospital Third Military Medical University Chongqing China H Corresponding author Hanjian Du M.D. Department of Radiology Southwest Hospital Third Military Medical University Chongqing China. Ph 086-23-68754419 Fax 086-23-65463026 E-mail bigcrab551@163.com Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License http creativecommons.org licenses by-nc-nd 3.0 . Reproduction is permitted for personal noncommercial use provided that the article is in whole unmodified and properly cited. Received 2011.03.31 Accepted 2011.07.12 Published 2011.08.13 Abstract BACKGROUND AND PURPOSE The present study was designed to detect the abnormalities of the cerebral grey-matter density in subcortical ischemic vascular dementia patients by FSL-VBM method to promote the early diagnosis of it. METHODS N ine subcortical ischemic vascular dementia patients and nine age-matched normal controls underwent MRI brain structure scanning that was performed on a SIEMENS AVANTO 1.5 Tesla scanner and standard T1-weighted high-resolution anatomic scans of MPRAGE sequence were obtained. The 3-demensional MPRAGE images were processed with FSL-VBM package and the cerebral gray matter density was compared between the subcortical ischemic vascular dementia patients and normal controls. RESULTS Compared with the normal control group the cerebral gray matter density of subcortical ischemic vascular dementia patients was found significantly decreasing including brain regions of thalamus parietal
