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Báo cáo y học: "Microarray Analysis of Differential Gene Expression Profile in Peripheral Blood Cells of Patients with Human Essential Hypertension"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Microarray Analysis of Differential Gene Expression Profile in Peripheral Blood Cells of Patients with Human Essential Hypertension. | Int. J. Med. Sci. 2011 8 168 International Journal of Medical Sciences 2011 8 2 168-179 Research Paper Microarray Analysis of Differential Gene Expression Profile in Peripheral Blood Cells of Patients with Human Essential Hypertension Melvin T. Korkor1 Fan Bo Meng1 Shen Yang Xing2 Mu Chun Zhang3 Jin Rui Guo1 Xiao Xue Zhu1 Ping Yang1 H 1. Department of Internal Medicine and Cardiology China-Japan Union Hospital Norman Bethune College of Medicine Jilin University China 2. College of Animal Science and veterinary medicine Jilin University China 3. Department of Urology China-Japan Union Hospital Norman Bethune College of Medicine Jilin University China H Corresponding author Ping Yang Ph.D Department of Internal Medicine and Cardiology China-Japan Union Hospital Norman Bethune College of Medicine Jilin University China. Tel 0086-431-84995091 Fax 0086-431-84995091 E-mail pyang@jlu.edu.cn Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License http creativecommons.org licenses by-nc-nd 3.0 . Reproduction is permitted for personal noncommercial use provided that the article is in whole unmodified and properly cited. Received 2010.10.31 Accepted 2011.02.21 Published 2011.02.27 Abstract The polygenic nature of essential hypertension and its dependence on environmental factors pose a challenge for biomedical research. We hypothesized that the analysis of gene expression profiles from peripheral blood cells would distinguish patients with hypertension from normotensives. In order to test this total RNA from peripheral blood cells was isolated. RNA was reversed-transcribed and labeled and gene expression analyzed using significance Analysis Microarrays Stanford University CA USA . Briefly Significance Analysis Microarrays SAM thresholding identified 31 up-regulated and 18 down-regulated genes with fold changes of S2 or50.5 and q-value 55 in expression. Statistically significantly gene ontology GO function .