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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients. | Int. J. Med. Sci. 2006 3 92 Research paper International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3 3 92-96 2006 Ivyspring International Publisher. All rights reserved Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients Tsutomu Nakamura1 Takeshi Ioroi1 Toshiyuki Sakaeda1 Masanori Horinouchi1 Nobuhide Hayashi2 Kensuke Saito3 Mitsuro Kosaka3 Noboru Okamura4 Keiichi Kadoyama5 Shunichi Kumagai3 and Katsuhiko Okumura1 4 1. Department of Hospital Pharmacy School of Medicine Kobe University 7-5-2 Kusunoki-cho Chuo-ku Kobe 650-0017 Japan 2. Clinical Pathology and Immunology Department of Biomedical Informatics Kobe University Graduate School of Medicine 7-5-1 Kusunoki-cho Chuo-ku Kobe 650-0017 Japan 3. Dade Behring limited 1-3-17 Shinkawa Chuo-ku Tokyo 104-0033 Japan 4. Department of Clinical Evaluation of Pharmacotherapy Kobe University Graduate School of Medicine 1-5-6 Minatojima-minamimachi Chuo-ku Kobe 650-0047 Japan 5. Division of Molecular Regenerative Medicine Department of Biochemistry and Molecular Biology Osaka University Graduate School of Medicine 2-2 Yamadaoka Suita Osaka 565-0871 Japan Corresponding address Katsuhiko Okumura Ph.D. Department of Hospital Pharmacy School of Medicine Kobe University Chuo-ku Kobe 650-0017 Japan. Phone 81-78-382-6640. FAX 81-78-382-6676. E-mail okumurak@med.kobe-u.ac.ip Received 2006.03.16 Accepted 2006.05.05 Published 2006.05.17 Cystatin C Cys-C has been recently paid great attention as a better endogenous marker of the glomerular filtration rate than creatinine Cr . In this study the usefulness of Cys-C was compared with Cr in terms of the estimation of the steady-state serum trough concentrations of digoxin in Japanese patients. Forty patients treated with digoxin and 56 healthy elderly subjects were participated in this study. The serum levels of Cys-C and Cr in the patients were higher than those in the healthy elderly subjects but the increase of Cys-C was more .
