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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: An Increased Risk of Osteoporosis during Acquired Immunodeficiency Syndrome. | Int. J. Med. Sci. 2004 1 3 152-164 152 International Journal of Medical Sciences Review ISSN 1449-1907 www.medsci.org 2004 1 3 152-164 2004 Ivyspring International Publisher. All rights reserved An Increased Risk of Osteoporosis during Acquired Received 2004.4.20 Accepted 2004.7.05 Published 2004.8.05 Immunodeficiency Syndrome N. Annapoorna G.Venkateswara Rao N.S. Reddy P. Rambabu1 and K.R.S.Samabasiva Rao Centre for Biotechnology Acharya Nagarjuna University Nagarjunanagar Guntur- 522 510 A.P. India. Department of Venereology GGH SMC NTR University Of Health Sciences Vijayawada-520 002 A.P. India. Abstract Osteoporosis is characterized by decreased bone mineral density and mechanistic imbalances of bone tissue that may result in reduced skeletal strength and an enhanced susceptibility to fractures. Osteoporosis in its most common form affects the elderly both sexes and all racial groups of human beings. Multiple environmental risk factors like acquired immune deficiency syndrome AIDS are believed to be one of the causes of osteoporosis. Recently a high incidence of osteoporosis has been observed in human immunodeficiency virus HIV infected individuals. The etiology of this occurrence in HIV infections is controversial. This problem seems to be more frequent in patients receiving potent antiretroviral therapy. In AIDS the main suggested risk factors for the development of osteoporosis are use of protease inhibitors longer duration of HIV infection lower body weight before antiretroviral therapy high viral load. Variations in serum parameters like osteocalcin c-telopeptide levels of elements like Calcium Magnesium Phosphorus concentration of vitamin-D metabolites lactate levels bicarbonate concentrations amount of alkaline phosphatase are demonstrated in the course of development of osteoporosis. OPG RANKL RANK system is final mediator of bone remodeling. Bone mineral density BMD test is of added value to assess the risk of osteoporosis in patients infected with .
