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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: EGFR Expression in Gallbladder Carcinoma in North America. | Int. J. Med. Sci. 2008 5 285 International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2008 5 5 285-291 Ivyspring International Publisher. All rights reserved Research Paper EGFR Expression in Gallbladder Carcinoma in North America Matthew Kaufman1 H Bhoomi Mehrotra1 Sewanti Limaye1 Sherrie White2 Alexander Fuchs1 Yehuda Le- bowicz1 Sandy Nissel-Horowitz1 Adrienne Thomas1 1. Long Island Jewish Medical Center New Hyde Park NY 11040 USA 2. Hartford Hospital Hartford CT USA H Correspondence to Long Island Jewish Medical Center Division of Hematology Oncology 270-05 76th Avenue New Hyde Park NY 11040. Telephone 718-470-8934 Facsimile 718-470-0169 Email mkaufman@nshs.edu Received 2008.02.18 Accepted 2008.09.19 Published 2008.09.22 BACKGROUND Increased epidermal growth factor receptor EGF receptor expression has been noted in various cancers and has become a useful target for therapeutic interventions. Small studies from Asia and Australia have demonstrated EGFR over-expression in gallbladder cancer. We sought to evaluate the expression of EGFR in a series of 16 gallbladder cancer patients from North America. METHODS Using tumor registry data we identified 16 patients diagnosed with gall bladder carcinoma at our medical center between the years of 1998 and 2005. We performed a retrospective review of these patients charts obtained cell blocks from pathology archives and stained for EGFR and Her2 neu. RESULTS Fifteen of sixteen patients were noted to over-express EGFR. Three were determined 1 nine were 2 and three were 3 . Eight patients had poorly differentiated adenocarcinoma six had moderately differentiated and two had well-differentiated tumors. In this small series there was a trend toward shorter survival and more poorly differentiated tumors in patients with greater intensity of EGFR expression. One patient was EGFR negative but 3 for erb-2 Her 2-neu expression. No patient co-expressed EGFR and Her-2-neu. Median survival of patients in this series .
