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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Methods of preventing vinorelbine-induced phlebitis: an experimental study in rabbits. | Int. J. Med. Sci. 2008 5 218 International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2008 5 4 218-223 Ivyspring International Publisher. All rights reserved Research Paper Methods of preventing vinorelbine-induced phlebitis an experimental study in rabbits Emiko Kohno1 Saori Murase2 Mayumi Nishikata2 Noboru Okamura2 Sumio Matzno2 Takashi Kuwahara3 and Kenji Matsuyama4 1. Department of Hospital Pharmacy Kansai Medical University Takii Hospital 10-15 Fumizono-cho Moriguchi Osaka 570-8507 Japan 2. Department of Clinical Pharmacy School of Pharmaceutical Sciences Mukogawa Women s University 11-68 Kos-hien-Kyuban-cho Nishinomiya Hyogo 663-8179 Japan 3. Research Fellow Drug Safety Research Institute Otsuka Pharmaceutical Factory Inc. 115 Muya-cho Naruto Tokushima 772-8601 Japan 4. Department of Clinical Pharmacy Faculty of Pharmacy Keio University 1-5-30 Shibakoen Minato-ku Tokyo 105-8512 Japan Correspondence to Emiko Kohno MS Vice Director Department of Pharmacy Kansai Medical University Takii Hospital 10-15 Fumizono-cho Moriguchi Osaka 570-8507 Japan. Tel 81-6-6992-1001 Fax 81-6-6995-5425 E-mail kohnoe@takii.kmu.ac.jp Received 2008.05.09 Accepted 2008.07.21 Published 2008.07.22 Purpose In order to identify methods for preventing phlebitis caused by intravenous administration of vi-norelbine VNR we established a procedure for estimating the severity of phlebitis in an animal model. Methods Four different factors administration rate dilution flushing and infusion of fat emulsion were evaluated for alleviation of phlebitis caused by VNR infusion. VNR was diluted with normal saline to prepare test solutions with concentrations of 0.6 mg mL or 0.3 mg mL for infusion into the auricular veins of rabbits. Two days after VNR infusion the veins were subjected to histopathological examination. Results VNR did not cause obvious loss of venous endothelial cells the most sensitive and common feature of phlebitis but VNR infusion led to inflammatory cell infiltration
