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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The GRADE approach for assessing new technologies as applied to apheresis devices in ulcerative colitis | Ibargoyen-Roteta et al. Implementation Science 2010 5 48 http www.implementationscience.eom content 5 1 48 Implementation Science IMPLEMENTATION SCIENCE RESEARCH ARTICLE Open Access The GRADE approach for assessing new technologies as applied to apheresis devices in ulcerative colitis 1 11 1 t 11 Nora Ibargoyen-Roteta Inaki Gutierrez-Ibarluzea Rosa Rico-Iturrioz Marta López-Argumedo Eva Reviriego-Rodrigo1t Jose Luis Cabriada-Nuno2t Holger J Schunemann3t Abstract Background In the last few years a new non-pharmacological treatment termed apheresis has been developed to lessen the burden of ulcerative colitis UC . Several methods can be used to establish treatment recommendations but over the last decade an informal collaboration group of guideline developers methodologists and clinicians has developed a more sensible and transparent approach known as the Grading of Recommendations Assessment Development and Evaluation GRADE . GRADE has mainly been used in clinical practice guidelines and systematic reviews. The aim of the present study is to describe the use of this approach in the development of recommendations for a new health technology and to analyse the strengths weaknesses opportunities and threats found when doing so. Methods A systematic review of the use of apheresis for UC treatment was performed in June 2004 and updated in May 2008. Two related clinical questions were selected the outcomes of interest defined and the quality of the evidence assessed. Finally the overall quality of each question was taken into account to formulate recommendations following the GRADE approach. To evaluate this experience a SWOT strengths weaknesses opportunities and threats analysis was performed to enable a comparison with our previous experience with the SIGN Scottish Intercollegiate Guidelines Network method. Results Application of the GRADE approach allowed recommendations to be formulated and the method to be clarified and made more explicit and transparent. Two weak .
