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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Analysis of in vitro replicated human hepatitis C virus (HCV) for the determination of genotypes and quasispecies | Virology Journal BioMed Central Research Open Access Analysis of in vitro replicated human hepatitis C virus HCV for the determination of genotypes and quasispecies Dennis Revie1 Michael O Alberti1 Ravi S Braich2 4 Nickolas Chelyapov2 5 David Bayles2 John G Prichard3 and S Zaki Salahuddin 2 Address Department of Biology California Lutheran University Thousand Oaks California USA 2California Institute of Molecular Medicine Ventura California USA 3Ventura County Medical Center Ventura California USA 4Alnylam Pharmaceuticals Cambridge Massachusetts USA and 5University of Southern California Los Angeles California USA Email Dennis Revie - revie@clunet.edu Michael O Alberti - moalberti@uasom.uab.edu Ravi S Braich - rsbraich@gmail.com Nickolas Chelyapov- chelyapo@usc.edu David Bayles - dave@inlandbuilderssupply.com John G Prichard - johnprichard@mail.co.ventura.ca.us S Zaki Salahuddin - phoenix@cimm.net Corresponding author Published 29 September 2006 Received 08 September 2006 Accepted 29 September 2006 Virology Journal 2006 3 81 doi l0.l 186 1743-422X-3-81 This article is available from http www.virologyj.cOm content 3 1 81 2006 Revie et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Isolation and self-replication of infectious HCV has been a difficult task. However this is needed for the purposes of developing rational drugs and for the analysis of the natural virus. Our recent report of an in vitro system for the isolation of human HCV from infected patients and their replication in tissue culture addresses this challenge. At California Institute of Molecular Medicine several isolates of HCV called CIMM-HCV were grown for over three years in cell culture. This is a report of the analysis of CIMM-HCV isolates for
