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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Respiratory syncytial virus (RSV) attachment and nonstructural proteins modify the type I interferon response associated with suppressor of cytokine signaling (SOCS) proteins and IFN-stimulated gene-15 (ISG15) | Virology Journal BioMed Central Research Respiratory syncytial virus RSV attachment and nonstructural proteins modify the type I interferon response associated with suppressor of cytokine signaling SOCS proteins and IFN-stimulated gene-15 ISG15 Elizabeth C Moore Jamie Barber and Ralph A Tripp Open Access Address Department of Infectious Diseases Center for Disease Intervention University of Georgia Athens GA 30602 USA Email Elizabeth C Moore - ecmoore@uga.edu Jamie Barber - barber@uga.edu Ralph ATripp - ratripp@uga.edu Corresponding author Published 13 October 2008 Received II August 2008 Accepted 13 October 2008 Virology Journal 2008 5 116 doi 10.1186 1743-422X-5-116 This article is available from http www.virologyj.com content 5 1 1 16 2008 Moore et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Respiratory syncytial virus RSV is a major cause of severe lower airway disease in infants and young children but no safe and effective RSV vaccine is yet available. Factors attributing to this problem are associated with an incomplete understanding of the mechanisms by which RSV modulates the host cell response to infection. In the present study we investigate suppressor of cytokine signaling SOCS -1 and SOCS3 expression associated with the type I IFN and IFN-stimulated gene ISG -15 response following infection of mouse lung epithelial MLE-15 cells with RSV or RSV mutant viruses lacking the G gene or NS1 and NS2 gene deletions. Studies in MLE-15 cells are important as this cell line represents the distal bronchiolar and alveolar epithelium of mice the most common animal model used to evaluate the host cell response to RSV infection and exhibit morphologic characteristics of alveolar type II cells a primary cell type
