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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Short-term salivary acetaldehyde increase due to direct exposure to alcoholic beverages as an additional cancer risk factor beyond ethanol metabolism | OI m Journal of Experimental Clinical Cancer Research Short-term salivary acetaldehyde increase due to direct exposure to alcoholic beverages as an additional cancer risk factor beyond ethanol metabolism Lachenmeier and Monakhova BioMed Central Lachenmeier and Monakhova Journal of Experimental Clinical Cancer Research 2011 30 3 httpy wwwjeccr.com content 30 1 3 6 January 2011 Lachenmeier and Monakhova Journal of Experimental Clinical Cancer Research 2011 30 3 http www.jeccr.eom content 30 1 3 RESEARCH Journal of Experimental Clinical Cancer Research Open Access Short-term salivary acetaldehyde increase due to direct exposure to alcoholic beverages as an additional cancer risk factor beyond ethanol metabolism Dirk W Lachenmeier1 Yulia B Monakhova1 2 Abstract Background An increasing body of evidence now implicates acetaldehyde as a major underlying factor for the carcinogenicity of alcoholic beverages and especially for oesophageal and oral cancer. Acetaldehyde associated with alcohol consumption is regarded as carcinogenic to humans IARC Group 1 with sufficient evidence available for the oesophagus head and neck as sites of carcinogenicity. At present research into the mechanistic aspects of acetaldehyde-related oral cancer has been focused on salivary acetaldehyde that is formed either from ethanol metabolism in the epithelia or from microbial oxidation of ethanol by the oral microflora. This study was conducted to evaluate the role of the acetaldehyde that is found as a component of alcoholic beverages as an additional factor in the aetiology of oral cancer. Methods Salivary acetaldehyde levels were determined in the context of sensory analysis of different alcoholic beverages beer cider wine sherry vodka calvados grape marc spirit tequila cherry spirit without swallowing to exclude systemic ethanol metabolism. Results The rinsing of the mouth for 30 seconds with an alcoholic beverage is able to increase salivary acetaldehyde above levels previously judged to be
