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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Pain as a symptom of peripheral nerve sheath tumors: clinical significance and future therapeutic directions. | Journal of Brachial Plexus and Peripheral Nerve Injury BioMed Central Open Access Review Pain as a symptom of peripheral nerve sheath tumors clinical significance and future therapeutic directions Michael E Sughrue 1 Jon Levine2 and Nicholas M Barbaro1 Address Department of Neurological Surgery University of California at San Francisco 505 Parnassus Ave San Francisco California USA and 2Department of Medicine University of California at San Francisco 505 Parnassus Ave San Francisco California USA Email Michael E Sughrue - Sughruem@neurosurg.ucsf.edu Jon Levine - Jon.Levine@ucsf.edu Nicholas M Barbaro - BarbaroN@neurosurg.ucsf.edu Corresponding author Published 29 February 2008 Received 24 October 2007 Journal of Brachial Plexus and Peripheral Nerve Injury 2008 3 6 doi l0.ll86 1749-7221 -3- Accepted 29 February 2008 6 This article is available from http www.jbppni.cOm content 3 1 6 2008 Sughrue et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Tumors arising from the supporting cells of peripheral nerve sheaths are relatively uncommon neoplasms and as such many clinicians are unfamiliar with the details of their presentation diagnosis and management. Further little is known regarding the pathogenesis of these tumors how they cause symptoms and how to treat these symptoms. One classic symptom of peripheral nerve tumors is pain however there has been little formal discussion regarding the significance of pain in this setting. Here we present a brief review of the clinical significance of pain its relevance in pre-operative planning for the treatment of these tumors and what is known regarding the molecular mechanisms of pain generation by
