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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Prevention of Pulmonary Complications of Pneumoperitoneum in Rats. | Karapolat et al. Journal of Cardiothoracic Surgery 2011 6 14 http www.cardiothoracicsurgery.Org content 6 1 14 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Prevention of Pulmonary Complications of Pneumoperitoneum in Rats c s m I IX s k s k I s 1C I I V1 I I K S 1 I r-J I VI m 2 I I h i r i I m 11 I3 D I I IXLT S k z I - 4 I r W AW-Z SX zr-J I k k4 It ỉ z-xt- Vnc r4 Sdmi Kdrapoidi Sudt Gezer umrdn Yildirim Idina Dumlu Bdnu Kdidpoidi Ismet OZdydin Mehmet idSdi Abdulkadir Iskender5 Hdydti Kdndis6 Ayhdn Sdritds6 Abstract Background Cdrbon dioxide CO2 pneumoperitoneum fdcilitdtes the visualization of dbdomindl orgdns during idpdroscopic surgery. However the dssocidted incredse in intra-abdominal pressure cduses oxiddtive stress which contributes to tissue injury. Objective We investigdted the dbility of the dntioxiddnt dnd anti-inflammatory drug Erdosteine to prevent CO2 pneumoperitoneum-induced oxiddtive stress dnd infldmmdtory redctions in d rdt model. Methods Fourteen femdle ddult Wistdr dlbino rdts were divided into d control group Group A n 7 dnd dn Erdosteine group Group B n 7 . Group A received 0.5 cc ddy 0.9 NdCl dnd Group B received 10 mg kg ddy Erdosteine wds ddministered by gdvdge dnd mdintdined for 7 ddys prior to the operdtion. During the surgicdl procedure the rdts were exposed to CO2 pneumoperitoneum with dn intrd-dbdomindl pressure of 15 mmHg for 30 min. The peritonedl gds wds then desuffldted. The rdts were sdcrificed following 3 h of insuffldtion. Their lungs were removed histologicdlly evdludted dnd scored for intra-alveolar hemorrhdge dlveoldr edemd congestion dnd leukocyte infiltration. The results were stdtisticdlly dndlyzed. A vdlue of P 0.05 wds considered stdtisticdlly significdnt. Results Significdnt differences were detected in intraralveoldr hemorrhdge P 0.05 congestion P 0.001 dnd leukocyte infiltration P 0.001 in Group A compdred with Group B. However the differences in dlveoldr edemd were not stdtisticdlly .
