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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Patterns of pulmonary dysfunction in asbestos workers: a cross-sectional study | Abejie et al. Journal of Occupational Medicine and Toxicology 2010 5 12 http www.occup-med.eom content 5 1 12 JOURNAL OF OCCUPATIONAL MEDICINE ANDTOXICOLOGY RESEARCH Open Access Patterns of pulmonary dysfunction in asbestos workers a cross-sectional study Belayneh A Abejie1 Xiaorong Wang2 Stefanos N Kales3 and David C Christian 3 Abstract Background Restrictive patterns of pulmonary function abnormalities associated with asbestos exposure are well described. Studies are less consistent however regarding the association of asbestos inhalation with airway dysfunction and obstructive impairment. Methods We compared pulmonary function test results between 277 chrysotile exposed workers 22 non-smokers and 177 unexposed controls 50.3 non-smokers . Information on exposure and smoking were collected using a standardized questionnaire. Standardized spirometric and DCLO Measurement methods were utilized. CXRs were read based on ILO pneumoconiosis guidelines. Results Asbestos exposed subjects had significantly reduced FVC FEV1 FEV1 FVC and DLCO. Restricting the analysis to non-smokers asbestos workers still had about 3 lower FEV1 FVC ratio than controls but this difference did not reach statistical significance. Among exposed workers the presence of radiographic evidence of asbestosis further lowered FVC and DLCO but not FEV1 FVC compared to asbestos exposure without radiographic asbestosis. Additionally smoking asbestos workers had significantly lower DLCO compared to non-smoking workers. Conclusion Asbestos exposure especially when radiographic evidence of interstitial fibrosis from asbestosis is present leads to significant decreases in FVC FEV1 and the DLCO. However asbestos exposure alone is not significantly associated with a reduction of the FEV1 FVC. Smoking-asbestos workers had significantly lower DLCO than their nonsmoking counterparts. Whether asbestos interacts with smoking additively or synergistically on DLCO needs further investigation. Similarly further .
