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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Comparative analysis of induced sputum and bronchoalveolar lavage fluid (BALF) profile in asbestos exposed workers | Alexopoulos et al. Journal of Occupational Medicine and Toxicology 2011 6 23 http www.occup-med.eom content 6 1 23 _ JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY RESEARCH Open Access Comparative analysis of induced sputum and bronchoalveolar lavage fluid BALF profile in asbestos exposed workers z-s Z i I r- f I I 11 r r- 1 2 w-i f t -h n X-. I- Dc i I I v r 3 h ỉ l h1 m I i4A b Cz r r I I5 I rci r D lzz Ĩ I r 2 M V zd tvangelos C Alexopoulos Demosthenes Bouros Maria Dimadi Aneta Serbescu Giorgos Bakoyannis ana Fivos P Kokkinis6 Abstract Background Biological monitoring of healthy workers exposed to hazardous dusts lack validated screening tools. Induced sputum IS cellular profile was compared with bronchoalveolar lavage fluid BALF profile in asbestos exposed workers in order to assess its usefulness in monitoring workers exposed to asbestos for a long period of time. Methods IS and BALF analysis was performed in 39 workers of a car brakes and clutches factory that uses chrysotile asbestos. Selection criteria were an employment history of 15 years and the absence of a diagnosis of pneumonoconiosis. The type of cells the existence of dust cells of iron laden macrophages and of asbestos bodies were assessed and compared between IS and BALF samples. Results 35 IS samples 90 had dust cells 34 87 iron laden macrophages and in 8 samples 21 asbestos bodies were found. In most samples neutrophils were dominated. Samples with asbestos bodies ABs had significantly higher lymphocytes and lower neutrophils count compared with the samples without ABs. Macrophages and neutrophils in IS and BALF exhibited significant inter-relations Spearman s rho 0.26-0.29 p 0.05 while IS lymphocytes count showed an inverse relation with BALF neutrophils Spearman s rho -0.36 . Neutrophils and dust cells were highly correlated between the samples Spearman s rho 0.35 p 0.05 while IS dust cells and lymphocytes were inversely related Spearman s rho -0.36 p 0.05 . More years of employment in the .
