Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The impact of shift work induced chronic circadian disruption on IL-6 and TNF-a immune responses | van Mark et al. Journal of Occupational Medicine and Toxicology 2010 5 18 http www.occup-med.eom content 5 1 18 JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY RESEARCH Open Access The impact of shift work induced chronic circadian disruption on IL-6 and TNF-a immune responses 1 2 11 3 4 Anke van Mark Stephan W Weiler Marcel Schroder Andreas Otto Kamila Jauch-Chara David A Groneberg Michael Spallek5 Richard Kessel1 Barbara Kalsdorf6 Abstract AIM Sleep disturbances induce proinflammatory immune responses which might increase cardiovascular disease risk. So far the effects of acute sleep deprivation and chronic sleep illnesses on the immune system have been investigated. The particular impact of shift work induced chronic circadian disruption on specific immune responses has not been addressed so far. Methods Pittsburgh-Sleep-Quality-Index PSQI questionnaire and blood sampling was performed by 225 shift workers and 137 daytime workers. As possible markers the proinflammatory cytokines IL-6 and TNF-a and lymphocyte cell count were investigated. A medical examination was performed and biometrical data including age gender height weight waist and hip circumference and smoking habits were collected by a structured interview. Results Shift workers had a significantly higher mean PSQI score than day workers 6.73 vs. 4.66 p 0.001 . Day workers and shift workers had similar serum levels of IL-6 2.30 vs. 2.67 resp. p 0.276 TNF-a 5.58 vs. 5.68 resp. p 0.841 or lymphocytes count 33.68 vs. 32.99 resp. p 0.404 . Furthermore there were no differences in cytokine levels IL-6 p 0.761 TNF-a p 0.759 or lymphocyte count p 0.593 comparing the sleep quality within the cohorts. When this calculation of sleep quality was stratified by shift and day workers irrespective of their sleep quality day workers and shift workers had similar serum levels of IL-6 TNF-a or lymphocytes count. Multiple linear regression analysis showed a significant correlation of lymphocytes count and smoking habits.
