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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Ischemic stroke destabilizes circadian rhythms. | Journal of Circadian Rhythms BioMed Central Open Access Ischemic stroke destabilizes circadian rhythms He Meng1 Tiecheng Liu2 Jimo Borjigin2 and Michael M Wang 1 2 Address Department of Neurology University of Michigan Medical School Ann Arbor MI 48109 USA and 2Department of Molecular and Integrative Physiology University of Michigan Medical School Ann Arbor MI 48109 USA Email He Meng - hemeng@umich.edu Tiecheng Liu - tiecliu@umich.edu Jimo Borjigin - borjigin@umich.edu Michael M Wang - micwang@umich.edu Corresponding author Published 15 October 2008 Received 4 September 2008 Journal of Circadian Rhythms 2008 6 9 doi l0.ll86 l740-339l-6-9 Accepted I5 October 2008 This article is available from http www.jcircadianrhythms.com content 6 l 9 2008 Meng et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The central circadian pacemaker is a remarkably robust regulator of daily rhythmic variations of cardiovascular endocrine and neural physiology. Environmental lighting conditions are powerful modulators of circadian rhythms but regulation of circadian rhythms by disease states is less clear. Here we examine the effect of ischemic stroke on circadian rhythms in rats using high-resolution pineal microdialysis. Methods Rats were housed in LD 12 12 h conditions and monitored by pineal microdialysis to determine baseline melatonin timing profiles. After demonstration that the circadian expression of melatonin was at steady state rats were subjected to experimental stroke using two-hour intralumenal filament occlusion of the middle cerebral artery. The animals were returned to their cages and melatonin monitoring was resumed. The timing of onset offset and duration of melatonin secretion were calculated before and
