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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Time-of-day dependence of neurological deficits induced by sodium nitroprusside in young mice. | Sani et al. Journal of Circadian Rhythms 2011 9 5 http www.jcircadianrhythms.eom content 9 1 5 JOURNAL OF CIRCADIAN RHYTHMS RESEARCH Open Access Time-of-day dependence of neurological deficits induced by sodium nitroprusside in young mice Mamane Sani1 2 Hichem Sebai2 Naceur A Boughattas3 and Mossadok Ben-Attia2 Abstract Sodium nitroprusside SNP is widely used in pharmacological studies as a potent vasodilator or a nitric oxide donor. SNP-induced ataxic effects were assessed in mice by the Joulou-Couvoisier test. Swiss albino mice of both genders 2-8 weeks of age were acclimated at least for 2 weeks to 12 h light rest span 12 h dark activity span . In 2 and 4 week old mice maxima of ataxia were found following intraperitoneal administration of a dose ranging from 3 to 3.6 mg.kg-1 SNP at 1 and 13 HALO Hours After Light Onset . The sublethal toxicity was statistically dosing-time dependent c2 test P 0.005 . No rhythm was validated in neurotoxicity by cosinor analyses. At the 8th week of post-natal development PND SNP-induced ataxia was greatest at 1 HALO 69 in males vs. 49 in females and lowest at 13 HALO 21 in males vs. 11 in females c2 test P 0.00001 . Cosinor analysis also revealed no statistically significant rhythm in mice injected with 3 or 3.3 mg.kg-1. However a significant circadian t 24 h rhythm was detected by adjusted cosinor in 3.6 mg.kg-1-treated mice P 0.004 . In all studied groups SNP-induced motor impairment expressed in was lower during the dark than the light phase. Furthermore there was a non-significant gender-related difference in SNP-induced neuronal toxicity with the males more sensitive than females at every studied PND. The ataxic effects were inversely proportional to the lag time from injection and to the age of animals with P 0.05 only between 2 and 8 week old mice . These data indicate that both the administration time and age of the animal significantly affect the neurotoxic effects of SNP. Background Sodium nitroprusside Na2 Fe CN 5NO .
