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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Lack of association between stavudine exposure and lipoatrophy, dysglycaemia, hyperlactataemia and hypertriglyceridaemia: a prospective cross sectional study. | Sinxadi et al. AIDS Research and Therapy 2010 7 23 http www.aidsrestherapy.eom content 7 1 23 AIDS RESEARCH AND THERAPY RESEARCH Open Access Lack of association between stavudine exposure and lipoatrophy dysglycaemia hyperlactataemia and hypertriglyceridaemia a prospective cross sectional study 1 1 1 2 13 Phumla Z Sinxadi Jan-Stefan van der Walt Helen M Mcllleron Motasim Badri Peter J Smith Joel A Dave Naomi S Levitt3 Gary Maartens1 Abstract Background Stavudine continues to be widely used in resource poor settings despite its toxicity. Our objective was to determine association between plasma stavudine concentrations and lipoatrophy concentrations of glucose lactate and triglycerides. Methods Participants were enrolled in a cross-sectional study with lipoatrophy assessment oral glucose tolerance test fasting triglycerides finger prick lactate and stavudine concentrations. Individual predictions of the area under the concentration curve AUC were obtained using a population pharmacokinetic approach. Logistic regression models were fitted to assess the association between stavudine geometric mean ratio 1 and impaired fasting glucose impaired glucose tolerance hyperlactataemia hypertriglyceridaemia and lipoatrophy. Results There were 47 study participants with a median age of 34 years and 83 were women. The median body mass index and waist hip ratio was 24.5 kg m2 and 0.85 respectively. The median duration on stavudine treatment was 14.5 months. The prevalence of lipoatrophy impaired fasting glucose impaired glucose tolerance hyperlactataemia and hypertriglyceridaemia were 34 19 4 32 and 23 respectively. Estimated median interquartile range stavudine AUC was 2191 1957 to 2712 ng h mL. Twenty two participants had stavudine geometric mean ratio 1. Univariate logistic regression analysis showed no association between stavudine geometric mean ratio 1 and impaired fasting glucose odds ratio OR 2.00 95 CI 0.44 to 9.19 impaired glucose tolerance OR 1.14 95 CI 0.07 to 19.42 .
