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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Recent key advances in human immunodeficiency virus medicine and implications for China. | Sun et al. AIDS Research and Therapy 2010 7 12 http www.aidsrestherapy.eom content 7 1 12 AIDS RESEARCH AND THERAPY REVIEW Open Access Recent key advances in human immunodeficiency virus medicine and implications for China Kai Sun 1 2 Shuntai Zhou3 Ray Y Chen4 Myron S Cohen 1 and Fujie Zhang 3 5 Abstract In this article we summarize several recent major developments in human immunodeficiency virus treatment prevention outcome and social policy change. Updated international guidelines endorse more aggressive treatment strategies and safer antiretroviral drugs. New antiretroviral options are being tested. Important lessons were learned in the areas of human immunodeficiency virus vaccines and microbicide gels from clinical studies and additional trials in prevention especially pre-exposure prophylaxis are nearing completion. Insight into the role of the virus in the pathogenesis of diseases traditionally thought to be unrelated to acquired immunodeficiency syndrome has become a driving force for earlier and universal therapy. Lastly we review important achievements of and future challenges facing China as she steps into her eighth year of the National Free Antiretroviral Treatment Program. Introduction Antiretroviral therapy ART has evolved from monotherapy with zidovudine AZT to the use of combination nucleoside reverse transcriptase inhibitors NRTIs to triple therapy with highly active antiretroviral therapy HAART to today s numerous combinations drawn from 6 classes and 32 drugs including fixed dose formulations approved by the United States US Food and Drug Administration FDA 1 . Treatment goals have also progressed from achieving viral suppression to regimen simplification to long term durability and to the present paradigm of treatment as prevention. In the past 2 decades HIV mortality has dramatically decreased reflecting the success of ART 2 3 . New drugs with fewer side effects and lower pill burden have made long term viral suppression a reality. As death .