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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem | JOURNAL OF BIOMEDICAL SCIENCE Chen et al. Journal of Biomedical Science 2011 18 49 http www.jbiomedsci.eom content 18 1 49 NSC The cost of publication in Journal of Biomedical Science Is borne by the National Science Council Taiwan REVIEW Open Access Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells Pei-Min Chen1 Men-Luh Yen2 Ko-Jiunn Liu3 Huey-Kang Sytwu4 and B-Linju Yen1 5 Abstract In recent years a large number of studies have contributed to our understanding of the immunomodulatory mechanisms used by multipotent mesenchymal stem cells MSCs . Initially isolated from the bone marrow BM MSCs have been found in many tissues but the strong immunomodulatory properties are best studied in BM MSCs. The immunomodulatory effects of BM MSCs are wide extending to T lymphocytes and dendritic cells and are therapeutically useful for treatment of immune-related diseases including graft-versus-host disease as well as possibly autoimmune diseases. However BM MSCs are very rare cells and require an invasive procedure for procurement. Recently MSCs have also been found in fetal-stage embryo-proper and extra-embryonic tissues and these human fetal MSCs F-MSCs have a higher proliferative profile and are capable of multilineage differentiation as well as exert strong immunomodulatory effects. As such these F-MSCs can be viewed as alternative sources of MSCs. We review here the current understanding of the mechanisms behind the immunomodulatory properties of BM MSCs and F-MSCs. An increase in our understanding of MSC suppressor mechanisms will offer insights for prevalent clinical use of these versatile adult stem cells in the near future. Keywords mesenchymal stem cells bone marrow fetal multilineage differentiation immunomodulation T lymphocytes natural killer lymphocytes dendritic cells major histocompatibility complex MHC molecules 1. Mesenchymal stem cells Definition and functional capacity Human mesenchymal stem cells MSCs are a population
