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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Characteristics of CD8+ T cell subsets in Chinese patients with chronic HIV infection during initial ART. | Jiao et al. AIDS Research and Therapy 2011 8 15 http www.aidsrestherapy.eom content 8 1 15 AIDS RESEARCH AND THERAPY RESEARCH Open Access Characteristics of CD8 T cell subsets in Chinese patients with chronic HIV infection during initial ART Yanmei Jiao Wei Hua Tong Zhang Yonghong Zhang Yunxia Ji Hongwei Zhang and Hao Wu Abstract Background CD8 T cells may play an important role in protecting against HIV. However the changes of CD8 T cell subsets during early period of ART have not been fully studied. Methods Twenty-one asymptomatic treatment-naive HIV-infected patients with CD4 T cells less than 350 cells pl were enrolled in the study. Naive central memory CM effective memory EM and terminally differentiated effector EMRA CD8 cell subsets and their activation and proliferation subsets were evaluated in blood samples collected at base line and week 2 4 8 and 12 of ART. Results The total CD8 T cells declined and the Naive and CM subsets had a tendency of increase. Activation levels of all CD8 T cell subsets except EMRA subset decreased after ART. However proliferation levels of total CD8 T cells EMRA EM and CM subsets increased at the first 4 weeks of ART then decreased. Proliferation level of the naive cells decreased after ART. Conclusion The changes of CD8 T cell subsets during initial ART are complex. Our results display a complete phenotypical picture of CD8 cell subsets during initial ART and provide insights for understanding of immune status during ART. Background CD8 T cells play an important role in protection against intracellular pathogens. Eliminating CD8 T lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia which was again suppressed coincident with the reappearance of SIV-spe-cific CD8 T cells. Antiviral CD8 T cells controlled the acute viremic phase of the infection resulting in the establishment of the viral set point 1-3 . Many studies 4-6 evaluated the changes of CD4 cell subsets during .
