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Hướng dẫn định lượng kháng sinh trẻ em Các bảng sau đây không áp dụng cho dùng thuốc kháng sinh ở trẻ sơ sinh. Khi tính toán một liều kháng sinh trẻ em, giữ tình trạng lâm sàng của bệnh nhân trong tâm trí và chắc chắn để so sánh kết quả với những liều thông thường cho người lớn để không vượt quá hướng dẫn dùng thuốc | Figure 2. Urban and Craig Pulse-Dosing Nomogram gentamicin and tobramycin 5 mg kg Time After Start of Infusion h From Urban et al. Curr Qin Top Infect Dis. 1997 17 236-55. Used with permission. Antimicrobial Dosing Pediatric Antimicrobial Dosing Definitions of Age Categories Neonate fuU-term newborn 0-4 weeks postnatal age Infant l month to 1 year of age Child l-12 years of age Adolescent 13-18 years of age Adult 18 years of age Table 16. Creatinine Clearance-Estimating Method in Pediatric Patients With stable Renal Function Age K Low birth weight 1 y 0.33 Full term 1 y 0.45 2-12 y 0.55 13- to 21-year-old female 0.55 13- to 21-year-old male 0.70 a ClCr K X L SCr ClCr creatinine clearance in mL min 1.73 m2 K age-specific constant of proportionality L length in cm SCr serum creatinine concentration in mg dL. Antimicrobial Dosing Pediatric Antimicrobial Dosing Guidelines The following tables do not apply to the dosing of antimicrobials in neonates. When calculating a pediatric antimicrobial dose keep the patient s clinical condition in mind and be sure to compare the results with those of the usual adult dose so as not to exceed usual adult-dosing guidelines. For antiparasitic or antimalarial agents see Red book or consult a pediatric infectious diseases specialist. Red book Report of the Committee on Infectious Diseases 26th ed. Elk Grove Village IL American Academy of Pediatrics 2003. p. 744-70 Table 4.13 and 4.14 . Table 17. Pediatric Antibacterial Dosing Guidelines3 Antimicrobial Usual dally dose Max dally dose Dose adjustment for renal Impairment CICr 50 mUmin CICr 50 mUmin CICr 10-49 mUmin CICr 10 mưmin or anuric amikacin 15-22.5 mg kg 24h divided q8h Monitor serum levels see recommendations in Table 21 and Table 22 See aminoglycoside-dosing protocol Table 21 and Table 22 amoxicillin Infants 3 mo 20-30 mg kg 24h divided ql2h 2-3 g 24h CỈQr 31-49 Use usual daily dose ƠQr 10-30 10 mg kg dose ql2h 10 mg kg dose q24h Infants 3 mo and children 25-50 mg kg 24h divided
