Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Chủ đề Kaposi sarcoma HBV mãn tính phát hiện một phần cải thiện. Interferon-alpha có hiệu quả lâu dài trong 30-40% bệnh nhân mãn tính HBV. Interferon-alpha có hiệu quả trong dài hạn 25% bệnh nhân viêm gan C mãn tính. | Fig. 3.30 Action of interferon-alpha on various viral structures. General Non-antiretroviral Antiviral Drugs 207 208 Antiviral Agents Table 3.26 Clinical Studies and Reports that Support the Use of Interferon-Alpha Topic Findings Reference Kaposi s sarcoma Partial improvement. 19-20 Chronic HBV Interferon-alpha has long-term effectiveness in 30-40 of patients with chronic HBV. 35-40 287 Chronic HCV Interferon-alpha has long-term effectiveness in 25 of patients with chronic HCV. HCV genotype 1 most prevalent in the United States has the lowest response rate. 287-294 Subcutaneous application of interferon-alpha May cause exacerbation of asthma in those previously predisposed to asthma. 294 295 Condylomata acuminata Partial improvement. 286 Psoriasis May worsen with interferonalpha treatment. 295 Lichen planus May improve or worsen with interferon-alpha treatments 286 Molluscum contagiosum virus MCV Overall response rates to systemic interferon-alpha range from 30-46 the majority of which are partial responses. 296-300 Fatigue. Fever. Myalgias. Lethargy. Headaches influenza-like syndrome . Central nervous system dysfunction including depression. Gastrointestinal disturbances. Bone marrow suppression. Bone marrow suppression often occurs when this medication is combined with other medications. General Non-antiretroviral Antiviral Drugs 209 Table 3.27 Treatment with Interferon-Alpha Symptom Treatment Chronic HBV Intron A children 3.0 million IU 3 times a week for first week. Escalate dose to 6 million max 10 million 3 times a week for 16-24 weeks. Intron A adults 30-35 million IU week 5 million IU daily or 10 million 3 times a week for 16 weeks . Chronic HCV Intron A 3.0 million IU 3 times a week. Continue treatment to 18-24 months if ALT is normal at 16 weeks of therapy. HPV treated with Intron A Intron A Inject 1.0 million IU into each lesion 3 times a week for 3 weeks with a maximum of 5 lesions per session. HPV treated with Alferon N Alferon N Inject 0.05 ml 250 000
