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Tên cấu trúc và thương hiệu được đưa ra trong hình. 2,17. NFV nguyên nhân mạnh và bền ức chế sự nhân lên của virus (như indinavir và ritonavir) khi được sử dụng kết hợp với hai chất tương tự nucleoside (267). Nếu điều trị kháng virus cứu hộ khi xảy ra đủ hiệu lực thuốc | Antiretroviral Drugs to Treat Human Immunodeficiency Virus Infections 75 prescribing PIs. Cannabinoids do not have any effect on antiretroviral efficacy 266 . Nelfinavir NFV Viracept FDA-approved in March 1997 nelfinavir NFV is a powerful and well-tolerated drug which is indicated in initial combination regimens for HIV therapy. The actual effect and mechanism of action for nelfinavir on the clinical progression of HIV infection have not been determined. The structure and brand names are given in Fig. 2.17. NFV causes potent and durable suppression of viral replication like indinavir and ritonavir when used in combination with two nucleoside analogues 267 . If salvage antiretroviral treatment when insufficient drug potency occurs resistance develops pharmacological issues arise or poor adherence to other therapies occurs is needed a possible replacement for indinavir and ritonavir is nelfinavir combined with two nucleoside analogs 268 . Nelfinavir is either a tablet or a powder to be taken orally usually three times a day with a meal or a light snack. The powder can be added to a variety of liquids including water milk formula soy milk or dietary supplements. All of the liquid must be consumed to obtain the maximum effect of the drug. Children can be given the oral powder with physicians determining the dosage for children under 2 years of age. Children 2-13 years of age are given doses of 20-30 mg kg of body Fig. 2.17 Trade names structure and uses of Nelfinavir. 76 Antiviral Agents weight 9-13.6 mg lb of body weight three times a day with food. Adults and teenagers are usually given 750-mg tablets three times a day with food 269 . Both nelfinavir and indinavir have no effect on accelerated bone loss 270 . Adverse Events When compared with other PIs nelfinavir has a more favorable side effect profile 138 . The majority of its adverse effects are of mild intensity. Diarrhea. Diarrhea is the most common side effect occurring in 13 to 20 of treated patients 138 . .
