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hội chứng Stevens-Johnson, nhức đầu, buồn nôn / nôn mửa và những người khác như được liệt kê dưới SQV những người khác được liệt kê dưới SQV và RTV Tiêu chảy và những người khác được liệt kê dưới Như liệt kê theo SQV và RTV SQV và RTV Buồn nôn, tiêu chảy sulfonamide, lovastatin, simavastatin, triazolam, midazolam, | Indinavir IDV Nelfinavir NFV Amprenavir APV Lopinavir Fosamprenavir GW 433908 Erythematous macules and papules dry skin alopecia paronychia pyogenic granulomas and others listed under SQV rare Stevens-Johnson syndrome Same as listed under SQV Macules and papules - pruritis Rare Stevens-Johnson syndrome others as listed under SQV As listed under SQV Rash 1 develop Stevens-Johnson syndrome Atazanavir BMS-232632 Enfuviritide ENF T-20 Injection site reactions Nephrolithiasis renal insufficiency or renal failure pharyngitis gastrointestinal upset anemia hepatitis and other listed under SQV and RTV Diarrhea and other as listed under SQV and RTV Perioral paraesthesias diarrhea headache nausea vomiting and others listed under SQV and RTV Diarrhea and others listed under SQV and RTV Nausea diarrhea Diarrhea jaundice Allergic reactions pain or numbness in feet or legs decreased appetite weakness constipation pancreatitits Same as listed under SQV and RTV Same as listed under SQV and RTV As listed under SQV and RTV As listed under SQV and RTV Sulfonamide lovastatin simavastatin triazolam midazolam ergot-based drugs cisapride pimozole Antiretroviral Drugs to Treat Human Immunodeficiency Virus Infections 32 Antiviral Agents Fig. 2.2 Sites of action of antiretroviral drugs. Nucleoside nucleotide and non-nucleoside reverse transcriptase RT inhibitors act at the same step in the replication of HIV. Nucleoside analogues when phosphorylated competitively inhibit RT by acting as an alternative substrate for the enzyme. Non-nucleoside analogues do not require phosphorylation but noncompetitively bind directly to the active site of RT. Protease inhibitors prevent the cleavage of viral polyproteins in the final stage of viral protein processing thus preventing the assembly of mature HIV virions. Fusion inhibitors prevent binding to the surface of the cell and subsequent infection of the cell. avenues for therapy. These include inhibitors that are active during the binding fusion and .
