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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: The radioprotective effects of the hexane and ethyl acetate extracts of Callophyllis japonica in mice that undergo whole body irradiation | J. Vet. Sci. 2008 9 3 281-284 JOURNAL OF Veterinary Science The radioprotective effects of the hexane and ethyl acetate extracts of Callophyllis japonica in mice that undergo whole body irradiation Jeongtae Kim1 1 Changjong Moon6 1 Heechul Kim1 Jinwoo Jeong1 Juyeon Lee1 Jihoon Kim1 2 3 1_2 4 5 2 5 6 1 2 3 Jin Won Hyun Jae Woo Park Mi Yeon Moon Nam Ho Lee Sung Ho Kim Youngheun Jee Taekyun Shin1 2 3 College of Veterinary Medicine and the Research Institute for Subtropical Agriculture and Biotechnology 2Applied Radiological Science Research Institute 3Department of Biochemistry College of Medicine 4Department of Nuclear and Energy Engineering College of Engineering Department of Chemistry College of Natural Science Cheju National University Jeju 690-756 Korea 6Department of Veterinary Anatomy College of Veterinary Medicine Chonnam National University Gwangju 500-757 Korea The radioprotective activity of extracts from the red seaweed Callophyllis C. japonica was investigated in mice that underwent whole-body exposure to gamma radiation. A methanol extract of C. japonica and its fractions hexane ethyl acetate EtOAc butanol and the remaining H2O were used. Each fraction 100 mg kg body weight was administered intraperitoneally i.p. 2 times into the BALB c mice once at 1 and once at 24 h before exposure to 9 Gray Gy of gamma radiation. Pre-irradiation administration of the hexane and EtOAc fractions saved the mice with their survival rates being greater than 80 at 30 days post-irradiation the mice that were pretreated with the other fractions showed survival rates lower than 20 over the same time period. To examine the effect of each C. japonica fraction on the survival of intestinal and bone marrow stem cells the number of intestinal crypts and bone marrow cells in the gamma-irradiated mice were examined. Pre-treatment of mice i.p. 100 mg kg body weight at 1 and 24 h before irradiation with the hexane or EtOAc fraction prior to 6-Gy irradiation significantly protected the
